Pickens Homes with Mixed Use Style

Welcome to Pickens, a charming city located in Pickens County, South Carolina. Known for its scenic beauty and friendly community, Pickens offers a wonderful blend of small-town charm and modern amenities.

If you are looking for homes with a mixed-use style in Pickens, you are in the right place. These properties seamlessly combine residential and commercial spaces, offering a unique and versatile living experience. Imagine having your cozy home upstairs and a trendy cafe or boutique shop downstairs - the possibilities are endless with mixed-use style homes.

Whether you are a young professional looking to live and work in the same space or an entrepreneur wanting to start a business from home, homes with mixed-use style in Pickens provide the perfect solution. Enjoy the convenience of having everything you need right at your doorstep while being part of a vibrant and thriving community.

Explore the real estate options in Pickens and discover the beauty of homes with mixed-use style. Experience the best of both worlds in this picturesque city where small-town charm meets modern innovation. Find your dream home in Pickens and embrace a lifestyle that is as unique and diverse as you are.

Newest Pickens Homes with Mixed Use Style

$995,000

3 Beds ⋅ 2.5 Baths ⋅ 1597019 MLS

I am pleased to present a unique real estate opportunity in the heart of Upstate South Carolina: a beautiful traditional home accompanied by the turnkey Laurel Mountain Inn. The custom-built primary residence features over 2,300 square feet of craftsmanship with an open floor plan, a main-level primary bedroom, three bedrooms, 2.5 bathrooms, and an attached office. The property also includes a full walkout basement ready to be finished as additional living space or a rental unit. The adjacent Laurel Mountain Inn sits on nearly seven acres next to Table Rock State Park. This fully operational, five-room income-producing property comes with a complete vendor list and an excellent reputation. Situated off Scenic Highway 11 near Caesars Head and Lake Keowee, it is a premier destination for nature enthusiasts and an ideal investment for hospitality entrepreneurs or event venue developers. While offering a private mountain lifestyle, the property remains conveniently located 30 minutes from Travelers Rest and 45 minutes from downtown Greenville. Showings are limited to qualified buyers and require a minimum 3-hour notice.

133 Hiawatha Trail, Pickens

$680,000

2 Beds ⋅ 1 Baths ⋅ 1595914 MLS

Tons of options with this new property featuring 23+ acres of mature forests with a new garage/ cabin combo. You can live in it as-is, or live in it while you built your main home, then use the current home as a guest house. The home is built with heavy duty all wood construction, but the walls are not load bearing, so you could take all of them out and convert the entire building into a workshop/ garage, or eliminate the garage and turn it all into living space. It would be great as a garage as the floors are 6" thick concrete, with 12' ceilings, plus its wired for heavy duty 220 garage appliances. The property offers 3 creeks, hardwood forests, multiple gardens with a solar powered creek watering system, ATV/ bike trails, walking paths along the creek. This property would serve as a great multifamily compound or as a ranch. Its unrestricted, so use your imagination. The property goes up the hill and has a great homesite with panoramic views .

3306 Moorefield Memorial Highway, Pickens

$275,000

3 Beds ⋅ 2 Baths ⋅ 1564752 MLS

Mixed-Use Investment Opportunity — 4612 Moorefield Memorial Hwy, Pickens, SC Rare multi-use gem in a prime, high-visibility location on a major highway with approximately 7,000 vehicles passing daily! Located just a few blocks from the Pickens County offices, this versatile property is perfect for investors seeking dual rental income or an owner-operator ready to live and work under one roof. Endless Possibilities This flexible space is ideal for a wide range of uses — HVAC or plumbing company, dental practice, insurance office, car lot, and more. The upstairs one-bedroom apartment offers built-in income potential to help offset your overhead. First Floor Two spacious office rooms plus a large reception/waiting area — perfect for a professional practice, storefront, or business headquarters. Also includes a cozy galley kitchen, full bathroom, and a utility room with laundry hookups. Second Floor A charming one-bedroom apartment featuring its own full bathroom, kitchen, and living area — ideal as a long-term rental for immediate income or as additional workspace. Outdoor Space Plenty of off-street parking for clients, plus a large fenced area at the rear of the property with room to build a larger garage. Whether you're growing your investment portfolio or looking for a space where business and life come together, this property checks every box. Priced to sell — owner is motivated and ready to consider all offers! All information is deemed accurate but not guaranteed.

4612 Moorefield Memorial Highway, Pickens

$280,000

1 Baths ⋅ 1556635 MLS

Storybook property with right on the Oolenoy River. There are numerous options with this property, it features an office/ efficiency apartment with a single car garage that could be finished into a bedroom. You could build onto this or keep it as-is while you built your new home. It could also be a guest quarters or maybe a weekend rental. The land is mostly pasture, so it would be great as a farm, campground, maybe a music venue, or even a combination of all of these. This property features 3.2 acres, but the best feature of this property is the beautiful and relaxing sound of the rushing waters of the river. It also has a very nice creek running along the full length of the property that joins the river. All of this is right in the heart of one of the most beautiful parts of the Upstate and nestled at the foot of the mountains.

716 Sliding Rock Road, Pickens

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The Listings data contained on this website comes from various participants of The Multiple Listing Service of Greenville, SC, Inc. Internet Data Exchange. IDX information is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. The properties displayed may not be all the properties available. All information provided is deemed reliable but is not guaranteed. © 2026 Greater Greenville Association of REALTORS®. All Rights Reserved. Last Updated